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Modulatory effects of endothelin‐1 on purinergic and adrenergic components of sympathetically‐mediated contractile activity of rabbit saphenous artery
Author(s) -
MutafovaYambolieva Violeta N.,
Radomirov Radomir G.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13198.x
Subject(s) - yohimbine , purinergic receptor , prazosin , medicine , endocrinology , stimulation , adenosine , adrenergic , endothelin 1 , muscle contraction , chemistry , contraction (grammar) , antagonist , receptor
1 The present study has been performed to evaluate the modulatory effects of endothelin‐1 (ET‐1) on the purinergic and adrenergic components of sympathetically‐mediated contractile responses of endothelium‐free rabbit saphenous artery preparations. 2 ET‐1 increased the smooth muscle tone, the pD 2 value being 7.77 ± 0.05. 3 Postjunctionally, ET‐1 enhanced the responses to exogenous adenosine 5′‐triphosphate (ATP) and did not influence those to exogenous noradrenaline (NA). 4 ET‐1 increased the contractile responses to short‐lasting and to long‐lasting electrical field stimulation at a frequency of 5 or 10 Hz, showing a tendency towards decreasing the prazosin‐sensitive component and increasing the mATP‐sensitive component of the contractile responses. 5 In prazosin‐treated preparations ET‐1 increased the residual mATP‐sensitive responses and this effect was more pronounced after yohimbine. 6 In mATP‐treated preparations ET‐1 increased the residual electrically‐induced contractions and this increase was abolished after yohimbine. 7 It is suggested that ET‐1 modulates co‐transmission in the rabbit saphenous artery by potentiating postjunctionally the purinergic component of the contractile responses to both exogenous ATP or electrical stimulation.