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Differential modulation of κ and μ opioid antinociception by the glycine/NMDA receptor agonist D‐serine
Author(s) -
Hunter J.C.,
Atwal P.,
Woodruff G.N.,
Singh L.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13181.x
Subject(s) - nmda receptor , chemistry , pharmacology , agonist , opioid , glycine , opioid receptor , nociception , serine , receptor , biochemistry , medicine , amino acid , phosphorylation
D‐Serine, a selective agonist for the strychnine‐insensitive glycine allosteric site associated with the NMDA receptor‐ion channel complex, was found to modulate differentially the antinociception produced by κ and μ‐opioid receptor agonists in the rat formalin test. D‐Serine (100 μg, i.c.v.) attenuated the antinociception produced by the selective κ‐opioid agonist, enadoline (0.003–0.1 mg kg −1 , s.c.) against the tonic, but not acute, phase of the formalin response. Conversely, D‐serine potentiated the antinociception produced by morphine (0.3–10 mg kg −1 , s.c.) against both the acute and tonic phases. These results demonstrate an important interaction between the opioid and NMDA/glycine systems in the control of nociceptive information possibly at different levels of the neuraxis.