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Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin
Author(s) -
Szilvassy Z.,
Ferdinandy P.,
Bor P.,
Jakab I.,
Szilvassy J.,
Nagy I.,
Lonovics J.,
Koltai M.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13180.x
Subject(s) - cyclic gmp , vasodilation , nitroglycerin (drug) , ischemic preconditioning , medicine , cyclic guanosine monophosphate , guanosine , anesthesia , ischemia , drug tolerance , cardiology , pharmacology , chemistry , nitric oxide , biochemistry
A preceding right ventricular overdrive pacing (VOP) of 500 b.p.m. for 5 min, markedly reduced the severity of global myocardial ischaemia produced by a subsequent 5‐min VOP in conscious rabbits. This VOP‐induced preconditioning developed in parallel with an increase in cardiac cyclic guanosine 3′: 5′‐monophosphate (cyclic GMP) content. VOP‐induced preconditioning was abolished when the animals had been made tolerant to the vasodilator effect of nitroglycerin (NG). In the heart of the NG‐tolerant rabbits, neither VOP nor preconditioning increased cyclic GMP content. This suggests that changes by NG tolerance of cyclic GMP metabolism may account for the loss of VOP‐induced preconditioning.