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Recovery after dietary vitamin E supplementation of impaired endothelial function in vitamin E‐deficient rats
Author(s) -
Rubino Annalisa,
Burnstock Geoffrey
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13103.x
Subject(s) - endocrinology , medicine , sodium nitroprusside , vitamin , vitamin e , vasodilation , endothelium , vitamin e deficiency , vitamin a deficiency , endothelial dysfunction , biology , nitric oxide , retinol , antioxidant , biochemistry
1 Thoracic aortae, isolated from rats supplemented with dietary vitamin E after vitamin E deficiency, were analysed for changes in vascular reactivity. 2 Following 4 or 12 months of dietary vitamin E deficiency, endothelium‐dependent vasodilator responses to acetylcholine were significantly impaired. However, when animals were fed after the first 4 months of vitamin E deprivation with a vitamin E‐supplemented diet for 8 months, endothelium‐mediated responses were completely restored. 3 In contrast, the endothelium‐independent vasodilator or vasoconstrictor responses to sodium nitroprusside and noradrenaline, respectively were not altered either by vitamin E deficiency or supplementation. 4 These data indicate that vitamin E supplementation reversed the impairment of endothelial cell function which occurs during vitamin E deficiency.