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Triflocin, a novel inhibitor for the Na‐HCO 3 symport in the proximal tubule
Author(s) -
Belachgar Fouzia,
Hulin Philippe,
Anagnostopoulos Takis,
Planelles Gabrielle
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13096.x
Subject(s) - cotransporter , hyperpolarization (physics) , ouabain , symporter , biophysics , epithelial polarity , amiloride , chemistry , intracellular ph , membrane potential , necturus , intracellular , biochemistry , sodium , membrane , biology , stereochemistry , transporter , nuclear magnetic resonance spectroscopy , organic chemistry , gene
1 Triflocin, applied at millimolar concentration hyperpolarizes the basolateral membrane of Necturus proximal convoluted tubular cells, in vivo.2 Barium, 2.5 × 10 −3 m , ouabain, 10 −3 m , or amiloride 10 −4 m , fail to prevent this hyperpolarization. 3 Triflocin has no effect on the intracellular chloride activity. 4 In physiological acid base conditions, Triflocin increases intracellular pH. 5 Upon an acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. 6 It is concluded that, Triflocin inhibits the basolateral electrogenic Na‐(HCO 3 ) n > 1 cotransport in proximal tubules.