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Evidence from desensitization studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion
Author(s) -
Connolly Gerald P.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13079.x
Subject(s) - superior cervical ganglion , purinergic receptor , adenosine triphosphate , adenosine , uridine triphosphate , desensitization (medicine) , receptor , medicine , endocrinology , ganglion , purine , chemistry , biology , neuroscience , biochemistry , nucleotide , enzyme , gene
Prolonged contact of the rat superior cervical ganglia (SCG) with the purine α,β‐methylene‐ATP (α,β‐Me‐ATP) selectively depressed responses to ATP and α,β‐Me‐ATP but not responses to uridine 5′‐triphosphate (UTP), potassium or adenosine. Prolonged contact with the pyrimidine UTP selectively depressed responses to UTP but not responses evoked by α,β‐Me‐ATP, potassium or adenosine. These results are consistent with the presence of P 2 ‐purinoceptors and pyrimidinoceptors on the rat SCG and the hypothesis that pyrimidinoceptors exist within the nervous system.