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Biological actions of purines on rat megakaryocytes: potentiation by adenine of the purinoceptor‐operated cytoplasmic Ca 2+ oscillation
Author(s) -
Uneyama Chikako,
Uneyama Hisayuki,
Takahashi Michihito,
Akaike Norio
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13076.x
Subject(s) - chemistry , purine metabolism , cytoplasm , biophysics , nucleic acid , guanine , adenine nucleotide , oscillation (cell signaling) , biochemistry , purinergic receptor , adenosine , biology , nucleotide , enzyme , gene
We have found that adenine enhanced the purinoceptor‐operated cytoplasmic Ca 2+ oscillation in rat megakaryocytes at submillimolar concentrations. Guanine and other nucleic acid bases had no effect on this system. Adenine enhanced the reaction intensity but had no effect on the threshold concentration of ATP to evoke the oscillation.