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Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle
Author(s) -
Chiou L.C.,
Chang C.C.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13060.x
Subject(s) - neuromuscular transmission , gabaa receptor , agonist , neostigmine , medicine , tetanic stimulation , endocrinology , muscle contraction , pharmacology , neuroscience , neurotransmission , receptor , biology
1 Effects of agonists and antagonists of peripheral and central benzodiazepine receptors (pBZR and cBZR) on neuromuscular transmission were studied in mouse isolated phrenic nerve‐diaphragm preparations. 2 Ro5–4864, a pBZR agonist, had no effect on the neuromuscular transmission but increased muscle contractility and antagonized the tetanic fade induced by neostigmine. 3 Ro5–4864 inhibited the regenerative tonic endplate depolarization caused by repetitive stimulation in the presence of neostigmine without affecting the amplitude and decay time of miniature and evoked single endplate potentials. 4 All the effects of Ro5–4864 were shared by PK11195, a pBZR antagonist, but not by clonazepam and flumazenil, a cBZR agonist and antagonist, respectively. 5 It is suggested that peripheral type benzodiazepine receptors modulate presynaptic function and muscle contraction.