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Differences in the effects of NK 1 ‐receptor antagonists, (±)‐CP 96,345 and CP 99,994, on agonist‐induced responses in guinea‐pig trachea
Author(s) -
Longmore J.,
Razzaque Z.,
Shaw D.,
Hill R.G.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13048.x
Subject(s) - agonist , guinea pig , substance p , receptor , medicine , endocrinology , b2 receptor , chemistry , smooth muscle , pharmacology , biology , neuropeptide , bradykinin
1 The effects of the NK 1 ‐receptor antagonists, (±)‐CP 96,345 and CP 99,994, on NK 1 ‐agonist evoked contractions were compared in isolated rings of guinea‐pig tracheal smooth muscle. 2 (±)‐CP 96,345 and CP 99,994 were similarly effective in antagonizing responses evoked by septide, whereas CP 99,994 was more effective than (±)‐CP 96,345 in inhibiting responses evoked by [Sar 9 Met 11 (O 2 )] substance P. 3 These results suggest that responses to septide and [Sar 9 Met 11 (O 2 )] substance P may be operated via different populations of NK 1 ‐receptors.