Premium
Evoked noradrenaline release in the rabbit ear artery: enhancement by purines, attenuation by neuropeptide Y and lack of effect of calcitonin gene‐related peptide
Author(s) -
Maynard K.I.,
Burnstock G.
Publication year - 1994
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1994.tb13040.x
Subject(s) - medicine , endocrinology , neuropeptide , calcitonin gene related peptide , adenosine , neuropeptide y receptor , chemistry , guinea pig , biology , receptor
1 Adenosine (30 μ m ) and its analogues 5′‐N‐ethylcarboxaminoadenosine (5 and 30 μ m ) and l‐phenylisopropyladenosine (5 and 30 μ m ), potentiated the evoked but not spontaneous release of tritiated noradrenaline in the rabbit central ear artery. 2 Prejunctional inhibition of the evoked but not spontaneous release of tritiated noradrenaline by 100 n m neuropeptide Y is greater at 2 min than at 10 min after superfusion of the peptide. 3 Calcitonin gene‐related peptide (2.63 to 263 n m ) did not affect the evoked or spontaneous release of tritiated noradrenaline in this preparation. 4 These results are discussed in terms of prejunctional modulation of sympathetic transmission in the rabbit central ear artery.