Premium
Release‐regulating dopamine autoreceptors in human cerebral cortex
Author(s) -
Fedele Ernesto,
Andrioli Gian Carlo,
Ruelle Antonio,
Raiteri Maurizio
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb13765.x
Subject(s) - quinpirole , autoreceptor , agonist , sulpiride , dopaminergic , dopamine receptor d2 , dopamine , dopamine receptor , chemistry , endocrinology , medicine , dopamine receptor d1 , sch 23390 , pharmacology , neuroscience , receptor , biology
Slices from fresh specimens of human neocortex which had to be removed during neurosurgery to reach subcortical tumours were labelled with [ 3 H]‐dopamine and stimulated electrically. Quinpirole, a selective dopamine D 2 receptor agonist, inhibited the stimulated tritium overflow (EC 50 = 25 n m ; maximal inhibition: about 80% at 10 μ m ). The selective D 1 receptor agonist, SKF 38393, was inactive up to 10 μ m . Quinpirole was antagonized by the D 2 receptor antagonist (−)‐sulpiride (apparent pA 2 = 8.26). Thus dopaminergic axon terminals in the human mesocortical pathway possess autoreceptors of the D 2 type.