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5‐HT 1B receptors mediate potent contractile responses to 5‐HT in rat caudal artery
Author(s) -
Craig Douglas A.,
Martin Graeme R.
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb13615.x
Subject(s) - 5 ht receptor , receptor , serotonin , endocrinology , pharmacology , biology , chemistry , medicine
5‐Hydroxytryptamine (5‐HT) evoked potent contractile responses in phenoxybenzamine‐treated ring segments of rat caudal artery, partially contracted with U46619. Responses were mimicked by 5‐HT 1 ‐selective agonists with the potency order: RU24969 > 5‐carboxamidotryptamine > 5‐HT = CP 93,129 > > sumatriptan. 8‐Hydroxy‐ N,N ‐dipropylaminotetralin was virtually inactive. Responses were unaffected by spiperone (0.1 μ m ) and mesulergine (1.0 μ m ), but were antagonized competitively by (±)‐cyanopindolol affording agonist‐independent p K B estimates of 8.4 to 8.9. The pharmacological profile of this receptor is consistent with that of the 5‐HT 1B subtype. Since the 5‐HT 1B receptor is the rodent homologue of the 5‐HT 1Dβ subtype, it might be anticipated that 5‐HT 1Dβ receptors will be found to mediate vasoconstrictor responses in non‐rodent species.