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The effect of lifarizine (RS‐87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil
Author(s) -
Brown C.M.,
Calder C.,
Alps B.J.,
Spedding M.
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb13549.x
Subject(s) - gerbil , dopamine , endocrinology , medicine , nicardipine , striatum , nimodipine , chemistry , calcium , ischemia
1 Unilateral ligation of the right common carotid artery in the anaesthetized gerbil for 3 h caused a 62.7% decrease in ipsilateral dopamine in the corpus striatum from 1.40 (± 0.13, n = 27) μg g −1 in the non‐ischaemic hemisphere to 0.47 (± 0.07, n = 27) μg g −1 in the ischaemic hemisphere (all results are expressed as mean ± s.e.mean). In sham‐operated animals there were no differences in the dopamine levels (1.31 ± 0.14 μg g −1 , n = 11, left; 1.27 ± 0.13 μg g −1 , n = 11 in the right hemisphere). Animals with intact communicating arteries in the circulus arteriosus were excluded. 2 Lifarizine (RS‐87476; 250, 500, but not 50, μg kg −1 , i.p.) protected against this dopamine depletion showing only a 9.2% decrease at 250 μg kg −1 , i.p. ( P < 0.01) and no decrease at 500 μg kg −1 , i.p. ( P < 0.01). 3 Nicardipine (250 μg kg −1 , p.o.) was effective when administered chronically once daily for 10 days (26.6% decrease, P < 0.05) but not when administered acutely at 50 μg kg −1 , i.p.