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Neurokinin‐induced changes in pial artery diameter in the anaesthetized guinea‐pig
Author(s) -
Beattie D.T.,
Stubbs C.M.,
Connor H.E.,
Feniuk W.
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb13454.x
Subject(s) - substance p , neurokinin a , agonist , neurokinin b , nk1 receptor antagonist , calcitonin gene related peptide , tachykinin receptor , endocrinology , medicine , guinea pig , chemistry , receptor , vasoconstriction , vasodilation , pharmacology , neuropeptide
1 The effects of selective neurokinin agents on pial artery diameter, measured with an on‐line image analyser, have been studied in anaesthetized guinea‐pigs in order to characterize the neurokinin receptors present on pial arteries. 2 Perivascular injection of either substance P (0.01–1 μ m ) or the selective NK 1 receptor agonists, substance P methyl ester (SPOMe, 0.01–1 μ m ) and GR73632 (0.1 μ m ), increased pial artery diameter. 3 In contrast, the selective NK 2 receptor agonist, GR64349 (1 μ m ), produced a small vasoconstriction while the NK 3 receptor‐selective agonist, senktide (1 μ m ) was inactive. 4 Co‐administration of GR82334 (1 μ m ), a selective NK 1 receptor antagonist, inhibited the vasodilatation produced by SPOMe (0.1 μ m ) but not that caused by calcitonin gene‐related peptide (CGRP, 0.01 μ m ). 5 The results are consistent with an involvement of NK 1 receptors in the neurokinin‐induced increase in guinea‐pig pial artery diameter.