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Role of leukotrienes in airway hyperresponsiveness in guinea‐pigs
Author(s) -
Ishida Kiyoshi,
Thomson Randall J.,
Schellenberg R. Robert
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb12864.x
Subject(s) - guinea pig , airway hyperresponsiveness , medicine , biology , neuroscience , immunology , asthma , endocrinology
1 Repeated aerosolization of leukotriene C 4 (LTC 4 ) to guinea‐pigs produced leftward shift in their pulmonary resistance (R L ) dose‐response curves to inhaled acetylcholine (ACh) without increasing the maximum responses. 2 Repeated LTC 4 aerosolization did not increase airway eosinophils. 3 The 5‐lipoxygenase‐activating protein (FLAP) inhibitor, MK‐886, prevented the leftward shift in R L dose‐response curves to ACh following repeated antigen challenge in guinea‐pigs. 4 MK‐886 did not inhibit the increased maximal R L produced by repeated antigen challenge, nor inhibit the airway eosinophilia induced by repeated antigen challenge. 5 Our findings suggest that leukotrienes may account for the leftward shift in pulmonary resistance responses caused by antigen but do not cause the airway eosinophilia nor enhanced maximum bronchoconstrictor response to antigen.