Premium
Dose‐dependent effects of angiotensin converting enzyme (ACE) inhibitors on glomerular prostanoid production by normotensive rats
Author(s) -
Harding P.,
Stonier C.,
Aber G.M.
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb12804.x
Subject(s) - enalapril , captopril , prostacyclin , prostanoid , angiotensin converting enzyme , endocrinology , fosinopril , medicine , chemistry , angiotensin ii , prostaglandin , ace inhibitor , thromboxane , renin–angiotensin system , enzyme inhibitor , enzyme , biochemistry , platelet , blood pressure
1 This study was designed to investigate whether the angiotensin converting enzyme (ACE) inhibitors, captopril, enalapril and fosinopril have a dose‐dependent effect on the production of prostaglandin E 2 (PGE 2 ), prostaglandin I 2 (prostacyclin, PGI 2 ) and thromboxane A 2 (TxA 2 ) by glomeruli isolated from normotensive Wistar‐Kyoto rats. 2 Measurements of glomerular prostanoid production were made under basal conditions and in the presence of excess exogenous arachidonic acid. 3 All three ACE inhibitors demonstrated dose‐dependent effects upon glomerular prostanoid production which varied with the individual ACE inhibitor. 4 Enalapril induced a dose‐dependent increase in the ratio of (PGE 2 + PGI 2 )/TxA 2 , from 2.17 ± 0.20 to 5.35 ± 0.84 and to 10.0 ± 1.16 with the low and high doses of enalapril respectively. In contrast, the high dose of captopril tended to reduce the ratio when compared to the low dose. 5 The results obtained in this study suggest that although all three ACE inhibitors appear to induce prostacyclin synthetase and/or modulate phospholipase A 2 (PLA 2 ) activity, these effects differ with the ACE inhibitor studied and the dose employed. 6 This study has demonstrated dose‐dependent effects of three ACE inhibitors on glomerular prostanoid production which may be significant in modulating glomerular haemodynamics and growth characteristics of glomerular cells.