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5‐Hydroxyindole slows desensitization of the 5‐HT 3 receptor‐mediated ion current in N1E‐115 neuroblastoma cells
Author(s) -
Kooyman André R.,
Hooft Johannes A.,
Vijverberg Henk P.M.
Publication year - 1993
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1993.tb12795.x
Subject(s) - desensitization (medicine) , 5 ht receptor , receptor , serotonin , chemistry , dopamine , endocrinology , ion channel , biophysics , neuroblastoma , ion , medicine , pharmacology , neuroscience , biology , biochemistry , cell culture , genetics , organic chemistry
Effects of 5‐hydroxyindole (5‐OHi) on 5‐HT 3 receptor‐operated ion current were investigated in voltage‐clamped N1E‐115 neuroblastoma cells. In the presence of 1 m m 5‐OHi, the amplitudes of inward currents induced by the agonists 5‐hydroxytryptamine (5‐HT), 2‐methyl‐5‐HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5‐OHi selectively modifies the desensitization of the 5‐HT 3 receptor‐mediated ion current.