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Changes in purinergic responses of the rabbit isolated central ear artery after chronic electrical stimulation in vivo
Author(s) -
Maynard K.I.,
Loesch A.,
Burnstock G.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14532.x
Subject(s) - purinergic receptor , stimulation , in vivo , endocrinology , medicine , human ear , electrophysiology , chemistry , biology , adenosine , physics , microbiology and biotechnology , acoustics
1 The effect of chronic (4–16 days) electrical stimulation (5 Hz, 0.3 ms, 4–10 V) of the great auricular nerve in vivo on sympathetic cotransmission in the rabbit isolated central ear artery was examined. 2 Chronic stimulation had no significant effect on frequency‐dependent (4–60 Hz) neurogenic contractions or contractile responses induced by exogenous noradrenaline (0.1–300 μ m ). 3 In contrast, contractions induced by exogenous α,β‐methylene ATP (10.0 μ m ) were significantly decreased in preparations from 16‐day stimulated animals in comparison with sham‐operated, 4‐day and 8‐day chronically stimulated animal groups. 4 It is concluded that chronic electrical stimulation of nerves supplying the ear artery may lead to the selective alteration of postjunctional P 2x ‐purinoceptor mechanisms, while the effects mediated by postjunctional α 1 ‐adrenoceptors remain unchanged.