Premium
The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia
Author(s) -
Buisson A.,
Plotkine M.,
Boulu R.G.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14410.x
Subject(s) - nitric oxide synthase , neuroprotection , nitric oxide , glutamate receptor , middle cerebral artery , ischemia , anesthesia , pharmacology , neurotoxicity , medicine , cerebral ischaemia , occlusion , toxicity , chemistry , receptor
Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition of NO synthase on focal cerebral ischaemia in rats, we studied the histological consequences of a middle cerebral artery (MCA) occlusion after post‐operative treatment with N G ‐nitro‐ l ‐arginine methyl ester, an inhibitor of nitric oxide synthase. We found a significant reduction of cortical (−43%) and striatal (−25%) necrotic volumes induced by MCA occlusion, indicating that NO synthesis plays an important role in the neurotoxic cascade leading to neuronal damage after focal cerebral ischaemia in rats.