Premium
Pharmacological evidence for distinct endothelin receptors in guinea‐pig bronchus and aorta
Author(s) -
Hay D.W.P.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14407.x
Subject(s) - guinea pig , bronchus , endothelin receptor , agonist , aorta , endocrinology , medicine , endothelin 1 , receptor , antagonist , chemistry , biology , anatomy , respiratory disease , lung
The ET A receptor antagonist, BQ‐123 (1 μ m ) potently antagonized endothelin‐1 (ET‐1) concentration‐response curves in guinea‐pig aorta (p K B = 7.1). However, 10 μ m BQ‐123 was without effect on ET‐1‐induced contractions in guinea‐pig bronchus. The ET B ‐selective agonist, sarafotoxin S6c did not contract the aorta but was a potent and effective contractile agonist in the bronchus. BQ‐123 (10 μ m ) was without effect on sarafotoxin S6c‐induced contractions in the bronchus. These data provide evidence for distinct endothelin receptors in guinea‐pig aorta and bronchus, which appear to be predominantly of the ET A and non‐ET A , perhaps ET B , subtypes, respectively.