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Steroid inhibition of oedema formation in the rat skin
Author(s) -
Ahluwalia A.,
Peers S.H.,
Flower R.J.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14386.x
Subject(s) - betamethasone , pharmacology , zymosan , endocrinology , topical steroid , chemistry , medicine , steroid , dexamethasone , immunology , biochemistry , in vitro , hormone
1 A model has been developed to compare the inhibitory effects of the topical steroid, betamethasone‐17‐valerate, to those of systemically administered betamethasone upon oedema responses induced by 5‐hydroxytryptamine (5‐HT), platelet activating factor (PAF) and zymosan‐activated serum (ZAS) ± prostaglandin E 1 (PGE 1 ), measured in the rat skin by use of 125 I‐labelled human serum albumin. 2 Systemic betamethasone had a selective, time‐ and dose‐dependent inhibitory effect upon oedema treatment, with 1 mg kg −1 and a 3 h pretreatment having the greatest effect of the doses and times employed. 3 Topical betamethasone inhibited the oedema responses to all of the stimuli showing no apparent selectivity. 4 Topical betamethasone inhibits inflammatory stimuli in a different manner from systemic betamethasone. The broad spectrum of inhibition suggests that topical betamethasone acts by affecting a fundamental feature of the inflammatory response common to all of the stimuli.