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Cannabinoid receptor agonists inhibit Ca current in NG108–15 neuroblastoma cells via a Pertussis toxin‐sensitive mechanism
Author(s) -
Caulfield M.P.,
Brown D.A.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14321.x
Subject(s) - pertussis toxin , cannabinoid , cannabinoid receptor , nifedipine , chemistry , receptor , biophysics , pharmacology , endocrinology , biology , g protein , biochemistry , calcium , agonist , organic chemistry
Cannabinoid receptor ligands irreversibly inhibited peak voltage‐activated Ca currents (44%) in NG108–15 cells; this inhibition was Pertussis toxin‐sensitive. Inhibition was largely due to a reduction in the ω‐conotoxin sensitive portion of high‐voltage activated (HVA) current, although there was also a significant decrease in low‐voltage activated current (56%) and in the nifedipine‐sensitive portion of HVA current (41%).