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Extracellular ATP and UTP exert similar effects on rat isolated hepatocytes
Author(s) -
Keppens Stefaan,
Vandekerckhove Ann,
Wulf Henri
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14278.x
Subject(s) - extracellular , microbiology and biotechnology , adenosine triphosphate , chemistry , biochemistry , biology , pharmacology , neuroscience
1 Extracellular UTP and ATP show obvious similarities in their control of several metabolic functions of rat isolated hepatocytes. 2 They have a similar time‐course and concentration‐dependency for the activation of glycogen phosphorylase, the generation of inositol trisphosphate (IP 3 ), the inhibition of glycogen synthase and the lowering of adenosine 3′: 5′‐cyclic monophosphate (cyclic AMP) levels. 3 There is a similar synergism of the nucleotides with glucagon in activating phosphorylase. 4 They undergo a similar inhibition by phorbol myristic acid of their glycogenolytic effect. 5 The ATP and UTP effect on IP 3 levels are not additive. 6 It is tentatively concluded that UTP and ATP use a common receptor.