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Increase in vascular permeability produced in rat airways by PAF: potentiation by adrenalectomy
Author(s) -
Boschetto Piera,
Musajo Francesco G.,
Tognetto Laura,
Boscaro Marco,
Mapp Cristina E.,
Barnes Peter J.,
Fabbri Leonardo M.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14263.x
Subject(s) - extravasation , evans blue , vascular permeability , adrenalectomy , platelet activating factor , endocrinology , medicine , bilateral adrenalectomy , dexamethasone , endogeny , pathology
1 The effect of bilateral adrenalectomy on the sensitivity of blood vessels in rat airways to mediators that increase vascular permeability was examined. 2 An increase in vascular permeability was induced by intravenous platelet activating factor (PAF, 50, 100, 500, 1000 ng kg −1 ) and measured by quantifying the extravasation of Evans blue dye. 3 PAF consistently increased the amount of Evans blue extravasation in the larynx, trachea, main bronchi and intrapulmonary airways in sham‐operated rats. 4 The magnitude of this extravasation was significantly greater in the larynx ( P < 0.05), trachea ( P < 0.05) and main bronchi ( P < 0.05) of the adrenalectomized rats than it was in these tissues of the sham‐operated rats. 5 When adrenalectomized rats were given subcutaneous dexamethasone (0.2 mg kg −1 4 h before PAF) the amount of plasma extravasation produced by PAF was decreased to the level of the sham‐operated rats. 6 We conclude that adrenalectomy potentiates the increase in airway vascular permeability induced by PAF in rats and that this effect may be due to the depletion of endogenous corticosteroids.