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Changes in plasma catecholamine and neuropeptide Y levels after sympathetic activation in dogs
Author(s) -
Poncet MarieFrance,
DamaseMichel Christine,
Tavernier Genevieve,
Tran MarieAntoinette,
Berlan Michel,
Montastruc JeanLouis,
Montastruc Paul
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14232.x
Subject(s) - yohimbine , neuropeptide y receptor , endocrinology , medicine , catecholamine , denervation , chemistry , sympathetic nervous system , antagonist , neuropeptide , blood pressure , receptor
1 Plasma levels of noradrenaline (NA) and neuropeptide Y (NPY) were evaluated in two experimental models associated with an increase in sympathetic tone: conscious dogs which were subject to either sinoaortic denervation or acute administration of the α 2 ‐adrenoceptor antagonist yohimbine. 2 Dogs that had undergone sinoaortic denervation exhibited a two fold increase in plasma NA without any change in NPY levels. 3 Yohimbine (0.05 mg kg −1 i.v. as a bolus) produced similar effects. A higher dose of yohimbine (0.5 mg kg −1 i.v.) increased both plasma NA (7 fold) and NPY (6.5 fold) levels. 4 The present results indicate that changes in plasma catecholamines and NPY are not always concomitant. They suggest that the simultaneous release of NA and NPY is only observed under in vivo conditions for a marked increase in sympathetic tone.