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5‐Methylurapidil may discriminate between α 1 ‐adrenoceptors with a high affinity for WB4101 in rat lung
Author(s) -
Hiramatsu Yoshinori,
Muraoka Ryusuke,
Kigoshi Shigeru,
Muramatsu Ikunobu
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14200.x
Subject(s) - prazosin , alpha (finance) , homogeneous , medicine , endocrinology , adrenergic receptor , chemistry , pharmacology , receptor , antagonist , physics , surgery , thermodynamics , construct validity , patient satisfaction
The α 1 ‐adrenoceptors of rat lung with a high affinity for [ 3 H]‐prazosin were subdivided into two populations (high and low affinity sites) by WB4101 and 5‐methylurapidil but the proportions were different between both drugs. After pretreatment with chlorethylclonidine, WB4101 recognized only high affinity sites, while 5‐methylurapidil still detected high and low affinity sites. These results indicate that α 1 ‐adrenoceptors with a high affinity for WB4101 are not homogeneous in the rat lung, suggesting the possible existence of a new α 1 ‐adrenoceptor subtype in addition to α 1A and α 1B subtypes.