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The selective NK 3 receptor agonist senktide excites a subpopulation of dopamine‐sensitive neurones in the rat substantia nigra pars compacta in vitro
Author(s) -
Keegan K.D.,
Woodruff G.N.,
Pinnock R.D.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb14199.x
Subject(s) - pars compacta , substantia nigra , agonist , dopamine , basal ganglia , medicine , endocrinology , pars reticulata , biology , receptor , excitatory postsynaptic potential , neurotransmitter , neuroscience , central nervous system , dopaminergic , inhibitory postsynaptic potential
Intra‐ and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine‐sensitive neurones were encountered which were potently excited by bath application of the NK 3 receptor agonist, senktide. On these senktide‐sensitive neurones, NK 1 and NK 2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.