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Effects of cicletanine on haemodynamics, arrhythmias and extent of necrosis during coronary ligation in rabbits
Author(s) -
Burton T.,
Chakrabarty S.,
Fluck D.S.,
Flores N.A.,
Sheridan D.J.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb13419.x
Subject(s) - hemodynamics , medicine , cardiology , necrosis , coronary occlusion , ischemia , ventricular fibrillation , ligation , heart rate , blood pressure , cardiac output , anesthesia
1 The effects of cicletanine on arrhythmias, haemodynamics and extent of necrosis during myocardial ischaemia were investigated in rabbits subjected to coronary ligation. 2 Cicletanine increased cardiac output prior to coronary occlusion ( P < 0.01) but had no other significant haemodynamic effects at this time and did not significantly alter heart rate, blood pressure or cardiac output during 30 min of ischaemia or 30 min of reperfusion. 3 Ventricular fibrillation and mortality were greater in control (65% and 60% respectively) than treated animals (15.4% and 15.4%, P < 0.01). 4 The extent of myocardial necrosis expressed as a percentage of the area at risk was also reduced by cicletanine from 61 ± 8% in controls to 37 ± 6% ( P < 0.05). 5 These findings indicate that cicletanine attenuates arrhythmias and preserves myocardium in the early phase of ischaemia and this effect appears to be independent of an established antihypertensive action.