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Stereospecific antiarrhythmic effects of naloxone against myocardial ischaemia and reperfusion in the dog
Author(s) -
Lee Andrew YingSiu
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb13406.x
Subject(s) - (+) naloxone , medicine , bradycardia , antagonist , anesthesia , opiate , cardiology , coronary occlusion , ischemia , heart rate , receptor , blood pressure
1 The effects of both the (−)‐ and (+)‐stereoisomers of naloxone in anaesthetized dogs with arrhythmias induced by acute coronary artery occlusion followed by reperfusion were investigated. 2 Following coronary artery occlusion and reperfusion, all dogs in the control group developed ischaemia‐ and reperfusion‐induced cardiac arrhythmias, bradycardia and hypotension. 3 The opiate antagonist (−)‐naloxone prevented the arrhythmias, bradycardia and hypotension due to myocardial ischaemia and reperfusion. 4 The (+)‐stereoisomer of naloxone, which is inactive as an opiate antagonist, was without beneficial effects. 5 These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism.