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The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning
Author(s) -
Vegh Agnes,
Papp Julius Gy,
Szekeres Laszlo,
Parratt James
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb13384.x
Subject(s) - methylene blue , cardiology , medicine , artery , occlusion , cyclic guanosine monophosphate , anesthesia , coronary occlusion , chemistry , nitric oxide , biochemistry , photocatalysis , catalysis
Short periods of coronary artery occlusion (2 × 5 min) markedly reduce the severity of arrhythmias and the changes in ST‐segment elevation and in the degree of inhomogeneity of conduction during a subsequent 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs. These changes were completely reversed if methylene blue (5 mg min −1 ) was infused into a side branch of the coronary artery throughout both the preconditioning and prolonged occlusions. These results suggest that the pronounced antiarrhythmic effects of preconditioning result from activation of guanylyl cyclase and result in increased levels of guanosine 3′:5′‐cyclic monophosphate.