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Evidence for a noradrenergic innervation to α 1A ‐adrenoceptors in rat kidney
Author(s) -
Blue David R.,
Vimont Rachel L.,
Clarke David E.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb12760.x
Subject(s) - prazosin , nitrendipine , urapidil , endocrinology , medicine , stimulation , norepinephrine , chemistry , methoxamine , adrenergic receptor , receptor , calcium , agonist , antagonist , dopamine , heart rate , blood pressure
1 Experiments were undertaken to characterize the α 1 ‐adrenoceptor subtype mediating vasoconstrictor responses to periarterial noradrenergic nerve stimulation (PNS) in the isolated perfused kidney of the rat. 2 Vasoconstrictor responses to nerve stimulation were inhibited by prazosin (10 n m ), 5‐methyl‐urapidil (30 n m ), and nitrendipine (1 μ m ) but were resistant to inhibition by chloroethylclonidine (100 μ m ). 3 5‐Methyl‐urapidil (30 n m ), chloroethylclonidine (100 μ m ) and nitrendipine (1 μ m ) did not inhibit the neuronal release of tritium from nerves loaded with [ 3 H]‐noradrenaline. 4 The results suggest that renovascular α 1A ‐adrenoceptors receive a noradrenergic innervation and that the innervated receptors are coupled to dihydropyridine‐sensitive calcium channels.