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Arterial and venous plasma concentrations of adenosine during haemorrhage
Author(s) -
Zhang Yong,
Lautt W. Wayne
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb09052.x
Subject(s) - adenosine , vasodilation , medicine , blood pressure , venous blood , anesthesia , cats , arterial blood
A haemorrhage model was used to impose severe metabolic stress in anaesthetized cats by removing blood (15.3 ml min −1 ) to attain an arterial pressure of ca. 50 mmHg for a 2 h period. Adenosine levels in central venous blood rose by 5 min, reached a peak of about 3.5 times control levels by 15 min and then returned to the basal level (1 μ m ) by 60 min. However, the adenosine concentration in arterial blood remained unchanged for the entire 2 h period of hypotension. These data demonstrate that haemorrhage results in rapid adenosine release, but the released adenosine is not able to serve a role as a systemic circulating vasodilator even in this severe model.