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The non‐peptide NK 1 receptor antagonist, (±)‐CP‐96,345, produces antinociceptive and anti‐oedema effects in the rat
Author(s) -
Birch P.J.,
Harrison S.M.,
Hayes A.G.,
Rogers H.,
Tyers M.B.
Publication year - 1992
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1992.tb09008.x
Subject(s) - nk1 receptor antagonist , nociception , hyperalgesia , antagonist , pharmacology , receptor , chemistry , receptor antagonist , peptide , substance p , medicine , biochemistry , neuropeptide
The non‐peptide NK 1 receptor antagonist, (±)‐CP‐96,345, has been evaluated for antinociceptive activity in two well‐characterized inflammatory pain models in the rat. (±)‐CP‐96,345 abolished carrageenin‐induced mechanical hyperalgesia, significantly reduced carrageenin‐induced paw oedema and attenuated the second phase of the formalin response. The results suggest that NK 1 receptor activation occurs during the induction of inflammatory pain states in the rat.