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Chronic treatment with the angiotensin I converting enzyme inhibitor, perindopril, protects in vitro carbachol‐induced vasorelaxation in a rat model of vascular calcium overload
Author(s) -
Henrion Daniel,
Chillon JeanMarc,
CapdevilleAtkinson Christine,
VinceneuxFeugier Marion,
Atkinson Jeffrey
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12534.x
Subject(s) - perindopril , mesenteric arteries , endocrinology , carbachol , medicine , nicotine , angiotensin ii , vasodilation , angiotensin converting enzyme , sodium nitroprusside , aorta , ace inhibitor , calcium , pharmacology , blood pressure , artery , nitric oxide , stimulation
1 Treatment of young rats with vitamin D 3 plus nicotine produced 31 and 4 fold increases in the calcium content of the aorta and the mesenteric arterial bed, respectively. 2 Aortic rings and perfused mesenteric arterial beds from vitamin D 3 /nicotine‐treated animals showed a diminished contractile response to noradrenaline in vitro . 3 In vascular preparations from vitamin D 3 /nicotine‐treated animals, precontracted with noradrenaline, relaxation by the endothelium‐dependent vasodilator, carbachol, was attenuated but responses to sodium nitroprusside were not modified. 4 Prolonged treatment with the angiotensin I converting enzyme inhibitor, perindopril, at a dose (1 mg kg −1 ) which did not significantly modify blood pressure, failed to prevent vascular calcium overload. 5 Perindopril treatment diminished noradrenaline‐evoked vasoconstrictor responses of aortic rings in both groups, but restored responses in mesenteric arterial beds of vitamin D 3 /nicotine‐treated rats. 6 Perindopril treatment also restored the maximal responses to carbachol of both aortic rings and mesenteric arterial beds of vitamin D 3 /nicotine‐treated rats. 7 In conclusion, in the vitamin D 3 plus nicotine model of calcium overload, reduced endothelial‐mediated relaxation can be prevented by perindopril treatment.