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Differential actions of platelet‐activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart
Author(s) -
Hu Weimin,
Man Ricky Y.K.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12504.x
Subject(s) - platelet activating factor , vasodilation , chemistry , coronary vasodilator , pharmacology , receptor , vasoconstrictor agents , medicine , biochemistry
Selectivity for blocking the coronary vasodilator and vasoconstrictor effects of platelet‐activating factor (PAF) in the rat perfused heart was observed with different PAF antagonists. CV‐6209 showed selectivity for blocking the vasodilator effect of PAF and a higher concentration (10 fold) was required to block the vasoconstrictor effect. The remaining PAF antagonists (FR‐900452, WEB 2086 and BN‐50739) showed selectivity for blocking the vasoconstrictor effect of PAF (10, 200 and 1000 fold respectively). A combination of low concentrations of CV‐6209 (10 n m ) with FR‐900452 (5 μ m ) or WEB 2086 (0.5 μ m ) was effective in blocking both the vasodilator and vasoconstrictor effects of PAF. CV‐6209 and WEB 2086 did not affect the vasodilator action of leukotriene B 4 (LTB 4 ) and the vasoconstrictor action of LTC 4 and LTD 4 . Our results support the hypothesis that the functionally opposite effects of PAF in the rat perfused heart may be mediated by different PAF receptor subtypes.