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Interaction of 1‐methyl‐4‐phenylpyridinium ion and tyramine with a site putatively involved in the striatal vesicular release of dopamine
Author(s) -
Vaccari A.,
Zompo M.,
Melis F.,
Gessa G.L.,
Rossetti Z.L.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12470.x
Subject(s) - dopamine , tyramine , dopamine transporter , catecholamine , neurotoxin , chemistry , tetrabenazine , striatum , vesicular monoamine transporter 2 , mptp , vesicular transport protein , vesicular monoamine transporter , dopamine plasma membrane transport proteins , biophysics , biochemistry , pharmacology , biology , dopaminergic , endocrinology , monoamine neurotransmitter , vesicle , receptor , serotonin , membrane
The neurotoxin MPP + potently inhibited the striatal binding of [ 3 H]‐tyramine, a putative marker for the vesicular transporter of dopamine, and provoked a massive in vivo release of striatal dopamine. Tetrabenazine, an established ligand for the vesicular catecholamine carrier, potently inhibited [ 3 H]‐tyramine binding, tyramine‐provoked striatal efflux of dopamine and the fast component of MPP + ‐induced dopamine release. It is concluded that MPP + in the striatum, besides interacting with additional intracellular targets, avidly binds at a vesicular site functionally involved with the outward transport of dopamine.