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Transepithelial water movement in response to carbamazepine, chlorpropamide and demeclocycline in toad urinary bladder
Author(s) -
Hirji M.R.,
Mucklow J.C.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12466.x
Subject(s) - chlorpropamide , toad , carbamazepine , chemistry , endocrinology , antidiuretic , medicine , metabolite , pharmacology , vasopressin , diabetes mellitus , psychiatry , epilepsy
1 Osmotic water movement across toad isolated hemibladders was measured by a gravimetric method. 2 The influence of carbamazepine, chlorpropamide and demeclocycline on the antidiuretic hormone (ADH)‐induced water flow rate was examined. 3 No antidiuretic activity due to carbamazepine alone was observed but a slight inhibition due to ADH‐induced water flow was observed in the presence of carbamazepine over a selected dose‐range. This was unexpected and is inconsistent with data from in vivo studies in man. 4 Chlorpropamide potentiated ADH‐induced water flow, in keeping with the hypothesis that chlorpropamide sensitizes the renal tubules to ADH‐induced water flow. 5 Demeclocycline inhibited ADH‐induced water flow. The mechanism of action remains unclear.