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The effects of idazoxan and other α 2 ‐adrenoceptor antagonists on food and water intake in the rat
Author(s) -
Jackson Helen C.,
Griffin I.J.,
Nutt D.J.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12416.x
Subject(s) - idazoxan , antagonist , endocrinology , medicine , chemistry , water intake , food intake , adrenergic receptor , prazosin , biology , receptor
1 Idazoxan (1, 3, 10 mg kg −1 , i.p.) produced a significant increase in food and water intake in freely feeding rats during the daylight phase. 2 The more selective and specific α 2 ‐adrenoceptor antagonists, RX811059 (0.3, 1, 3 mg kg −1 , i.p.) and RX821002 (0.3, 1, 3 mg kg −1 , i.p.), did not produce hyperphagia in rats, however, the highest dose produced a significant increase in water intake. 3 The peripherally acting α 2 ‐adrenoceptor antagonist, L‐659,066 (1, 3, 10 mg kg −1 , i.p.), did not affect food intake in the 4 h following injection, but the highest dose (10 mg kg −1 ), produced a large increase in water intake. 4 These results indicate that α 2 ‐adrenoceptor antagonists may increase water intake by a peripherally mediated mechanism. 5 The lack of effect of RX811059 and RX821002 on food intake contrasts with the large dose‐related increases induced by idazoxan and suggests that the hyperphagic effects of idazoxan are not due to α 2 ‐adrenoceptor blockade but may instead reflect its affinity for a non‐adrenoceptor site, a property not shared by the other α 2 ‐antagonists.