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Nedocromil sodium inhibits airway hyperresponsiveness and eosinophilic infiltration induced by repeated antigen challenge in guinea‐pigs
Author(s) -
Schellenberg R. Robert,
Ishida Kiyoshi,
Thomson Randall J.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12339.x
Subject(s) - ovalbumin , nedocromil sodium , nedocromil , bronchial hyperresponsiveness , airway resistance , acetylcholine , guinea pig , pharmacology , immunology , eosinophilia , eosinophil , chemistry , bronchoconstriction , methacholine , airway , medicine , asthma , endocrinology , antigen , anesthesia , lung , respiratory disease , pathology , alternative medicine , placebo
1 Repeated exposure to ovalbumin aerosol produced significant increases in epithelial eosinophils of airways of all sizes and produced increased pulmonary resistance (R L ) to inhaled acetylcholine (ACh) in guinea‐pigs. 2 Nedocromil sodium 10 mg ml −1 , by nebulization prior to each ovalbumin (OA) challenge inhibited both the airway eosinophilia and hyperresponsiveness to ACh. 3 Nedocromil sodium pretreatment (10 mg ml −1 by nebulization) 10 min prior to OA completely inhibited the acute bronchoconstrictor response to OA. 4 Our findings suggest that nedocromil sodium inhibits airway hyperresponsiveness by inhibiting eosinophilic infiltration, or by simultaneously inhibiting mechanisms involved in both processes.