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Human, pig and guinea‐pig bladder smooth muscle cells generate similar inward currents in response to purinoceptor activation
Author(s) -
Inoue Ryuji,
Brading Alison F.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12338.x
Subject(s) - purinergic receptor , adenosine , guinea pig , neurotransmission , biology , excitatory postsynaptic potential , chemistry , neuroscience , microbiology and biotechnology , endocrinology , biochemistry , receptor , inhibitory postsynaptic potential
The contribution of purinergic neurotransmission to bladder excitation in pigs and man is small. Exogenously‐applied adenosine‐trisphosphate (ATP) however, elicits large inward currents in dispersed bladder smooth muscle cells in both species. The essential properties of the ATP‐induced current in human and pig detrusor are similar and the current intensity is comparable to those in the guinea‐pig, which has a powerful purinergic excitatory innervation. This suggests that other features of the tissue such as the closeness of the innervation and the degree of cell‐to‐cell coupling may be important in determining the effectiveness of purinergic transmission.