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Pinacidil inhibits the ryanodine‐sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein
Author(s) -
Xiong Zhiling,
Kajioka Shunichi,
Sakai Takeshi,
Kitamura Kenji,
Kuriyama Hirosi
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12252.x
Subject(s) - pinacidil , glibenclamide , ryanodine receptor , potassium channel , vasodilation , antagonist , pharmacology , chemistry , nicorandil , intracellular , potassium channel opener , medicine , biophysics , endocrinology , biology , biochemistry , receptor , diabetes mellitus
Pinacidil, a potassium‐channel opener, inhibited the ryanodine‐sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP‐sensitive K‐channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.