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Coronary vasoconstriction in the conscious rabbit following intravenous infusion of l ‐N G ‐nitro‐arginine
Author(s) -
Humphries R.G.,
Carr R.D.,
Nicol A.K.,
Tomlinson W.,
O'Connor S.E.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12212.x
Subject(s) - vasoconstriction , vasodilation , nitric oxide , anesthesia , pharmacology , medicine , in vivo , lagomorpha , arginine , rabbit (cipher) , chemistry , biology , biochemistry , statistics , microbiology and biotechnology , mathematics , amino acid
Intravenous infusion of l ‐N G ‐nitro‐arginine, an inhibitor of endothelial nitric oxide (NO) synthesis, produced vasoconstriction in the coronary, cerebral, renal and duodenal vascular beds of the conscious rabbit. In this study, using radiolabelled microspheres, we provide in vivo evidence for a basal NO‐dependent vasodilator tone in the coronary vascular bed.