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Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat
Author(s) -
Grealy M.,
O'Donnell J.M.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12180.x
Subject(s) - idazoxan , yohimbine , endocrinology , prazosin , desipramine , medicine , sulpiride , atropine , corticosterone , prolactin , chemistry , hormone , antagonist , antidepressant , receptor , hippocampus
1 Acute intravenous administration of either clonidine (Clon) (50 μg kg −1 ) or desipramine (DMI) (5 mg kg −1 ) elicited a pulse of growth hormone (GH) and corticosterone secretion in conscious, unrestrained rats. 2 The responses to DMI were similar to those with Clon, except that the GH pulse following DMI was delayed and was not dose‐dependent. 3 The GH response to DMI was inhibited by prior administration of idazoxan (1 mg kg −1 ) or yohimbine (0.5 mg kg −1 ), but not by atropine (10 μg kg −1 ), sulpiride (5 mg kg −1 ) or prazosin (1 mg kg −1 ). 4 The corticosterone secretion following DMI was not altered by prior atropine, sulpiride or prazosin, but was augmented by idazoxan (1 mg kg −1 ). 5 GH secretion was not influenced by atropine, sulpiride, prazosin or idazoxan given alone. Idazoxan or yohimbine given alone elicited significant secretion of corticosterone. 6 It is concluded that i.v. DMI caused an activation through indirect mechanisms of α 2 ‐adrenoceptors specifically involved in hypothalamic‐pituitary regulation of GH release and also a distinct, independent and transient generalized activation of the pituitary‐adrenal axis.