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Influence of angiotensin II on the α‐adrenoceptors involved in mediating the response to sympathetic nerve stimulation in the rabbit isolated distal saphenous artery
Author(s) -
Dunn W.R.,
McGrath J.C.,
Wilson V.G.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb12123.x
Subject(s) - rauwolscine , prazosin , stimulation , medicine , angiotensin ii , endocrinology , antagonist , sympathetic nervous system , chemistry , receptor , blood pressure
Under normal experimental conditions, sympathetic nerve‐mediated responses to electrical field stimulation in the isolated distal saphenous artery of the rabbit are sensitive to prazosin (0.1 μ m ) and so, by definition, are mediated by α 1 ‐adrenoceptors. In the presence of angiotensin II (A II, 0.05 μ m ) however, a component of the response to nerve stimulation became resistant to prazosin. This ‘uncovered’ response was virtually abolished by the selective α 2 ‐adrenoceptor antagonist rauwolscine (1 μ m ), a concentration that in the absence of A II had enhanced nerve‐mediated responses. Exposure to A II therefore, allows the clear demonstration of a role for postjunctional α 2 ‐adrenoceptors in mediating the contractile response to sympathetic nerve stimulation in this arterial preparation.