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Prostaglandin E 1 decreases the low‐density‐lipoprotein entry into rabbit arterial wall
Author(s) -
Sinzinger H.,
Virgolini Irene,
Lupattelli Graziana,
Molinari E.,
Gerakakis A.,
Angelberger P.
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb09838.x
Subject(s) - endothelium , endocrinology , medicine , aorta , prostaglandin e1 , chemistry , prostaglandin , abdominal aorta , cholesterol , arterial wall , low density lipoprotein , in vivo , biology , microbiology and biotechnology
1 In 72 male rabbits fed a 1% cholesterol supplemented diet the effect of a 4 weeks daily infusion of prostaglandin E 1 (PGE 1 , 20 μg kg −1 min −1 over 2 h) on [ 125 I]‐low density lipoprotein (LDL) accumulation (10 μCi; 0.5 mg protein ml −1 ) was examined versus sham‐treatment after removal of the endothelium of the abdominal aorta by a Fogarthy catheter. 2 The uptake of [ 125 I]‐LDL was significantly ( P < 0.01) higher in endothelium‐free aortic segments (showing the highest peak maximum at around 12 h after 125 I‐injection) as compared to aortic segments with endothelium intact (showing the lowest uptake of [ 125 I]‐LDL with the peak maximum at 48 h, last control time). Segments with the endothelium restored showed a similar LDL‐retention curve to segments with endothelium however, being again significantly ( P < 0.01) higher. 3 PGE 1 ‐treatment caused reduction in LDL‐accumulation, being significantly ( P < 0.001) pronounced in segments without endothelium and in segments with endothelium restored. 4 The findings indicate a beneficial effect of PGE 1 in lipid metabolism by decreasing the LDL‐influx into the arterial wall in‐vivo.