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Effects of midaglizole, a new hypoglycaemic drug on the electrophysiological properties of guinea‐pig papillary muscle
Author(s) -
Noguchi Noriyasu,
Hasegawa Junichi,
Mashiba Hiroto
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb09826.x
Subject(s) - electrophysiology , guinea pig , papillary muscle , chemistry , antagonist , membrane potential , pharmacology , medicine , inhibitory postsynaptic potential , endocrinology , receptor , biochemistry
1 The electrophysiological effects of midaglizole, a new oral hypoglycaemic agent which is an α 2 ‐adrenoceptor antagonist, were assessed in the reserpinized ventricular myocardium of the guinea‐pig. 2 Midaglizole suppressed the maximal rate of rise (V̇ max ) and the amplitude of action potentials (APA) of the fast and the slow responses in a concentration‐dependent manner without influencing the resting potentials. 3 Voltage‐dependency of the V̇ max block of the action potentials by midaglizole (10 μ m ) did not appear in solutions containing various concentrations of KCl. 4 It is concluded that midaglizole has inhibitory effects on the fast Na + and slow Ca 2+ currents of the membrane independent of the blockade of myocardial α‐adrenoceptors, and that these effects may be significant in some clinical uses of the drug.