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Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum
Author(s) -
Takaki Miyako,
Nakayama Sosogu
Publication year - 1991
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1991.tb09809.x
Subject(s) - capsaicin , antidromic , stimulation , endocrinology , medicine , efferent , chemistry , neuropeptide , cholinergic , neuropeptide y receptor , substance p , peripheral nervous system , neuroscience , biology , central nervous system , receptor , afferent
1 The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin‐sensitive primary afferents in the guinea‐pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2 NPY inhibited or suppressed the cholinergic contractile response produced by electrical mesenteric nerve stimulation while leaving the contractile response to a threshold concentration of capsaicin. 3 NPY had no effect on motor responses produced by a submaximal concentration of substance P, the putative endogenous mediator of the ‘efferent’ function of sensory fibres in this preparation. 4 It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin‐sensitive nerves at interneuronal synapses.