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The effects of granisetron, ICS 205–930 and ondansetron on the visceral pain reflex induced by duodenal distension
Author(s) -
Moss Helen E.,
Sanger Gareth J.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb15836.x
Subject(s) - granisetron , distension , medicine , reflex , anesthesia , gastric distension , ondansetron , (+) naloxone , blood pressure , vagotomy , endocrinology , opioid , antiemetic , nausea , receptor
1 Distension of the duodenum in anaesthetized rats, by rapid application of intraluminal pressures (10–75 cmH 2 O), evoked falls in diastolic blood pressure and intragastric pressure. 2 The distension‐induced responses were blocked by pretreatment with morphine (20 mg kg −1 , s.c.), an action reversible by injection of naloxone (5 mg kg −1 , i.v.). 3 Bilateral cervical vagotomy reduced the distension‐evoked fall in intragastric pressure but had no effect on the corresponding fall in blood pressure. 4 Granisetron or ICS 205–930 (1–1000 μg kg −1 , i.v.) had no effects on duodenal intraluminal pressure, but reduced the responses to distension with a bell‐shaped dose‐response relationship. Ondansetron (1–1000 μg kg −1 , i.v.) did not reduce the reflex responses. 5 These results show that the 5‐HT 3 receptor antagonists used exerted different effects on the reflex responses to duodenal distension.