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Anti‐inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo
Author(s) -
Banks Barbara E.C.,
Dempsey Christopher E.,
Ver Charles A.,
Warner Jane A.,
Yamey Jill
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14707.x
Subject(s) - degranulation , nippostrongylus brasiliensis , compound 48/80 , mast cell , peptide , in vivo , chemistry , pharmacology , mepyramine , venom , immunology , biochemistry , biology , immune system , receptor , microbiology and biotechnology , antagonist
1 The relationship between the anti‐inflammatory activity of the bee venom peptide 401 in the carrageenin‐induced oedema of the rat hind paw and its mast cell degranulating activity has been reinvestigated. 2 Mast cell degranulation caused by compound 48/80 (10 mg kg −1 ) or by allergen challenge in rats sensitized to Nippostrongylus brasiliensis also suppressed rat hind paw oedema in the same test. 3 The anti‐inflammatory activities of peptide 401 and compound 48/80 were partially suppressed by pretreatment of rats with mepyramine and methysergide, at doses (2.5 mg kg −1 ) that completely suppressed skin reactions to these mast cell‐derived amines. Pretreatment of rats with compound 48/80 also suppressed the apparent anti‐inflammatory actions of peptide 401 and of compound 48/80. 4 Injection of peptide 401 together with carrageenin increased the inflammatory response in the rat hind paw. 5 The anti‐inflammatory activity of peptide 401 and of compound 48/80 in the carrageenin‐induced swelling of the rat hind paw arises from mast cell degranulation in vivo .