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Vasopressin and stress‐induced antinociception in the mouse
Author(s) -
Hart S.L.,
OluyomiXY A.O.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb14688.x
Subject(s) - vasopressin , (+) naloxone , arginine , chemistry , endocrinology , medicine , neuropeptide , pharmacology , arginine vasopressin receptor 1b , opioid , arginine vasopressin receptor 2 , receptor , biochemistry , amino acid
1 Arginine vasopressin produced antinociception in the hot‐plate test after intracerebroventricular injection (0.5 μg) and in the acetic acid abdominal constriction test after intraperitoneal injection (0.1 mg kg −1 ). 2 The antinociception produced by arginine vasopressin was sensitive to deamino(CH 2 ) 5 Tyr(Me) arginine vasopressin (0.5 μg i.c.v.; 0.1 mg kg −1 i.p.) but not to naloxone (5 μg i.c.v.; 2 mg kg −1 i.p.) 3 Arginine vasopressin when administered by the intracerebroventricular route, but not by the intraperitoneal route, produced characteristic behaviour which was sensitive to deamino(CH 2 ) 5 Tyr(Me) arginine vasopressin (0.5 μg, i.c.v.). 4 A 3 min swim at 20°C produced antinociception on the hot‐plate which was sensitive to naloxone (0.4 mg kg −1 , i.p.) but not to deamino(CH 2 ) 5 Tyr(Me) arginine vasopressin (0.5 μg, i.cv.). 5 The reduction in the number of acetic acid‐induced abdominal constrictions produced by a 30 s swim at 30°C was not sensitive to either naloxone (2 mg kg −1 , i.p.) or deamino(CH 2 ) 5 Tyr(Me) arginine vasopressin (0.1 mg kg −1 , i.p.). 6 Arginine vasopressin, at high doses, is antinociceptive in the mouse but does not appear to mediate stress‐induced antinociception in this species.